Toll-like receptor triggering augments activation of human mast cells by anti-citrullinated protein antibodies.

@article{Suurmond2015TolllikeRT,
  title={Toll-like receptor triggering augments activation of human mast cells by anti-citrullinated protein antibodies.},
  author={Jolien Suurmond and Felice Rivellese and Annemarie L. Dorj{\'e}e and Anne Bakker and Yoann Rombouts and Theo Rispens and G. Wolbink and Arnaud Zaldumbide and Rob C Hoeben and T. W. J. Huizinga and R. E. M. Toes},
  journal={Annals of the rheumatic diseases},
  year={2015},
  volume={74 10},
  pages={1915-23}
}
OBJECTIVE Mast cells may play a role in rheumatoid arthritis (RA), but activation of human mast cells in autoimmune settings has been little studied. Toll-like receptors (TLR) and Fcγ receptors (FcγR) are important receptors for cellular activation in the joint, but expression and stimulation of these receptors in human mast cells or the functional interplay between these pathways is poorly understood. Here, we analysed triggering of human mast cells via these receptors in the context of anti… CONTINUE READING

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