Toll-like receptor signalling

@article{Akira2004TolllikeRS,
  title={Toll-like receptor signalling},
  author={Shizuo Akira and Kiyoshi Takeda},
  journal={Nature Reviews Immunology},
  year={2004},
  volume={4},
  pages={499-511}
}
One of the mechanisms by which the innate immune system senses the invasion of pathogenic microorganisms is through the Toll-like receptors (TLRs), which recognize specific molecular patterns that are present in microbial components. Stimulation of different TLRs induces distinct patterns of gene expression, which not only leads to the activation of innate immunity but also instructs the development of antigen-specific acquired immunity. Here, we review the rapid progress that has recently… 

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TLDR
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Pathogen recognition with Toll-like receptors.

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Evolution and integration of innate immune recognition systems: the Toll-like receptors

  • K. Takeda
  • Biology
    Journal of endotoxin research
  • 2005
TLDR
In innate immunity, innate immunity represents a skilful system that senses microbial invasion and initiates appropriate immune responses, and TIR domain-containing adaptors play essential roles in TLR signaling.

Evolution and integration of innate immune recognition systems: the Toll-like receptors.

TLDR
In innate immunity, innate immunity represents a skillful system that senses microbial invasion and initiates appropriate immune responses, and TIR domain-containing adaptors play essential roles in TLR signaling.

Toll-like receptors and human pathology

TLDR
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Toll‐Like Receptors

TLDR
Mammalian TLRs (TLR1 to 13) that have an essential role in the innate immune recognition of microorganisms are discussed, and TLR‐mediated signaling pathways and antibodies that are available to detect specific TLRs are discussed.

Negative regulation of Toll-like receptor signaling pathway.

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