Toll-like receptor signaling inhibits structural development of the distal fetal mouse lung.

@article{Prince2005TolllikeRS,
  title={Toll-like receptor signaling inhibits structural development of the distal fetal mouse lung.},
  author={Lawrence S. Prince and Heather I Dieperink and Victor O. Okoh and German Alejandro Fierro-Perez and Roger L. Lallone},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2005},
  volume={233 2},
  pages={553-61}
}
We tested the hypothesis that innate immune signaling in utero could disrupt the structural development of the fetal lung, contributing to the pathogenesis of bronchopulmonary dysplasia. Injection of Escherichia coli lipopolysaccharide (LPS) into the amniotic fluid of E15 BALB/cJ mice increased the luminal volume density of fetal mouse lungs at embryonic day (E) 17 and E18. LPS also increased luminal volume and decreased distal lung branching in fetal mouse lung explants. This effect required… CONTINUE READING