Toll-like receptor-mediated immune responses in intestinal macrophages; implications for mucosal immunity and autoimmune diseases.

@article{Zhou2016TolllikeRI,
  title={Toll-like receptor-mediated immune responses in intestinal macrophages; implications for mucosal immunity and autoimmune diseases.},
  author={Zejun Zhou and Miao Ding and Lei Huang and Gary S. Gilkeson and Ren Lang and Wei Jiang},
  journal={Clinical immunology},
  year={2016},
  volume={173},
  pages={81-86}
}
Monocytes are precursors of macrophages and key players during inflammation and pathogen challenge in the periphery, whereas intestinal resident macrophages act as innate effector cells to engulf and clear bacteria, secrete cytokines, and maintain intestinal immunity and homeostasis. However, perturbation of toll-like receptor signaling pathway in intestinal macrophages has been associated with tolerance breakdown in autoimmune diseases. In the present review, we have summarized and discussed… CONTINUE READING
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