Toll-like receptor family members in skin fibroblasts are functional and have a higher expression compared to skin keratinocytes.

@article{Yao2015TolllikeRF,
  title={Toll-like receptor family members in skin fibroblasts are functional and have a higher expression compared to skin keratinocytes.},
  author={Cheng Yu Yao and Jang-hee Oh and Dong Hun Lee and Jung-Soo Bae and C. L. Jin and Chi-hyun Park and Jin Ho Chung},
  journal={International journal of molecular medicine},
  year={2015},
  volume={35 5},
  pages={1443-50}
}
Toll-like receptors (TLRs) are known to recognize not only pathogen-associated molecular patterns but also danger-associated molecular patterns. Recent studies have characterized the expression levels and functions of TLRs in human epidermal cells. However, the characteristics of TLR family members in human dermal fibroblasts have not been thoroughly studied. Therefore, the present study systematically investigated the expression levels of TLRs and their functional responses to each ligand in… CONTINUE READING
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