Toll-like receptor expression in murine DC subsets: lack of TLR7 expression by CD8 alpha+ DC correlates with unresponsiveness to imidazoquinolines.

@article{Edwards2003TolllikeRE,
  title={Toll-like receptor expression in murine DC subsets: lack of TLR7 expression by CD8 alpha+ DC correlates with unresponsiveness to imidazoquinolines.},
  author={Alexander D Edwards and Sandra S. Diebold and Emma Marie Caroline Slack and Hideyuki Tomizawa and Hiroaki Hemmi and Tsuneyasu Kaisho and Shizuo Akira and Caetano Reis e Sousa},
  journal={European journal of immunology},
  year={2003},
  volume={33 4},
  pages={827-33}
}
Toll-like receptors (TLR) recognize microbial and viral patterns and activate dendritic cells (DC). TLR distribution among human DC subsets is heterogeneous: plasmacytoid DC (PDC) express TLR1, 7 and 9, while other DC types do not express TLR9 but express other TLR. Here, we report that mRNA for most TLR is expressed at similar levels by murine splenic DC sub-types, including PDC, but that TLR3 is preferentially expressed by CD8 alpha(+) DC while TLR5 and TLR7 are selectively absent from the… CONTINUE READING
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