Toll-like receptor expression and function in the COV434 granulosa cell line.

@article{Price2012TolllikeRE,
  title={Toll-like receptor expression and function in the COV434 granulosa cell line.},
  author={Jennifer Claire Price and James F. Cronin and I Martin Sheldon},
  journal={American journal of reproductive immunology},
  year={2012},
  volume={68 3},
  pages={205-17}
}
PROBLEM Bacterial infections perturb ovarian follicle function, despite the lack of immune cells such as macrophages within healthy ovarian follicles. This study examined whether the granulosa cells that line ovarian follicles could, like macrophages, use Toll-like receptors (TLRs) to detect pathogen-associated molecular patterns (PAMPs) and initiate inflammation. METHOD OF STUDY The COV434 human granulosa and THP-1 macrophage cell lines were used to determine the expression of TLRs and… CONTINUE READING