Toll-like receptor downstream signaling

  title={Toll-like receptor downstream signaling},
  author={Taro Kawai and Shizuo Akira},
  journal={Arthritis Research & Therapy},
  pages={12 - 19}
The family of Toll-like receptors (TLRs) senses conserved structures found in a broad range of pathogens, causing innate immune responses that include the production of inflammatory cytokines, chemokines and interferons. The signal transduction is initiated from the Toll/interleukin-1 receptor (TIR) domain of TLRs after pathogen recognition. Almost all TLRs use a TIR-containing adapter MyD88 to activate a common signaling pathway that results in the activation of NF-kappaB to express cytokine… CONTINUE READING
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