Toll-like receptor and heme oxygenase-1 signaling in hepatic ischemia/reperfusion injury.

  title={Toll-like receptor and heme oxygenase-1 signaling in hepatic ischemia/reperfusion injury.},
  author={Xiu-da Shen and B. R. Ke and Yuan Zhai and Feng Gao and Ronald W Busuttil and Genhong Cheng and Jerzy W. Kupiec-Weglinski},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  volume={5 8},
Ischemia/reperfusion injury (IRI) represents the major problem in clinical liver transplantation. We have shown that toll-like receptor 4 (TLR4) signaling is specifically required in initiating antigen-independent IRI leading to liver inflammation, whereas local induction of anti-oxidant heme oxygenase-1 (HO-1) is cytoprotective. This study analyzes in vivo interactions between HO-1 and sentinel TLR system in the pathophysiology of liver IRI. Using a 90-min lobar warm ischemia model, wild type… CONTINUE READING


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