Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis.

@article{Rachmilewitz2004TolllikeR9,
  title={Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis.},
  author={Daniel Rachmilewitz and Kyoko Katakura and Fanny Karmeli and Tomoko Hayashi and Constantin Reinus and Bernard Rudensky and Shizuo Akira and Kiyoshi Takeda and J. Scott Lee and Kenji Takabayashi and Eyal Raz},
  journal={Gastroenterology},
  year={2004},
  volume={126 2},
  pages={520-8}
}
BACKGROUND & AIMS We tested whether the attenuation of experimental colitis by live probiotic bacteria is due to their immunostimulatory DNA, whether toll-like receptor (TLR) signaling is required, and whether nonviable probiotics are effective. METHODS Methylated and unmethylated genomic DNA isolated from probiotics (VSL-3), DNAse-treated probiotics and Escherichia coli (DH5 alpha) genomic DNA were administered intragastrically (i.g.) or subcutaneously (s.c.) to mice prior to the induction… CONTINUE READING
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