Toll-like receptor 9 signaling in dendritic cells regulates neutrophil recruitment to inflammatory foci following Leishmania infantum infection.

@article{Sacramento2015TolllikeR9,
  title={Toll-like receptor 9 signaling in dendritic cells regulates neutrophil recruitment to inflammatory foci following Leishmania infantum infection.},
  author={La{\'i}s Amorim Sacramento and Silvia Cellone Trevelin and Manuela Sales Lima Nascimento and Djalma Souza Lima-J{\'u}nior and Diego Lu{\'i}s Costa and Roque P Almeida and Fernando Q Cunha and Jo{\~a}o S. Silva and Vanessa Carregaro},
  journal={Infection and immunity},
  year={2015},
  volume={83 12},
  pages={
          4604-16
        }
}
Leishmania infantum is a protozoan parasite that causes visceral leishmaniasis (VL). This infection triggers dendritic cell (DC) activation through the recognition of microbial products by Toll-like receptors (TLRs). Among the TLRs, TLR9 is required for DC activation by different Leishmania species. We demonstrated that TLR9 is upregulated in vitro and in vivo during infection. We show that C57BL/6 mice deficient in TLR9 expression (TLR9(-/-) mice) are more susceptible to infection and display… CONTINUE READING
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Protective Role of 5-Lipoxigenase during Leishmania infantum Infection 702 Is Associated with Th17 Subset

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