Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice.

  title={Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice.},
  author={Kouichi Miura and Yuzo Kodama and Sayaka Inokuchi and Bernd E. Schnabl and Tomonori Aoyama and Hirohide Ohnishi and Jerrold M. Olefsky and David Brenner and Ekihiro Seki},
  volume={139 1},
BACKGROUND & AIMS Development of nonalcoholic steatohepatitis (NASH) involves the innate immune system and is mediated by Kupffer cells and hepatic stellate cells (HSCs). Toll-like receptor 9 (TLR9) is a pattern recognition receptor that recognizes bacteria-derived cytosine phosphate guanine (CpG)-containing DNA and activates innate immunity. We investigated the role of TLR9 signaling and the inflammatory cytokine interleukin-1beta (IL-1beta) in steatohepatitis, fibrosis, and insulin resistance… CONTINUE READING
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