Toll-like receptor 9-induced type I IFN protects mice from experimental colitis.

@article{Katakura2005TolllikeR9,
  title={Toll-like receptor 9-induced type I IFN protects mice from experimental colitis.},
  author={Kyoko Katakura and J. Scott Lee and Daniel Rachmilewitz and Gloria C. Li and Lars Eckmann and Eyal Raz},
  journal={The Journal of clinical investigation},
  year={2005},
  volume={115 3},
  pages={695-702}
}
Experimental colitis is mediated by inflammatory or dysregulated immune responses to microbial factors of the gastrointestinal tract. In this study we observed that administration of Toll-like receptor 9 (TLR9) agonists suppressed the severity of experimental colitis in RAG1-/- but not in SCID mice. This differential responsiveness between phenotypically similar but genetically distinct animals was related to a partial blockade in TLR9 signaling and defective production of type I IFN (i.e., IFN… CONTINUE READING
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Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

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