Toll-like receptor 9-induced type I IFN protects mice from experimental colitis.

  title={Toll-like receptor 9-induced type I IFN protects mice from experimental colitis.},
  author={Kyoko Katakura and J. Scott Lee and Daniel Rachmilewitz and Gloria C. Li and Lars Eckmann and Eyal Raz},
  journal={The Journal of clinical investigation},
  volume={115 3},
Experimental colitis is mediated by inflammatory or dysregulated immune responses to microbial factors of the gastrointestinal tract. In this study we observed that administration of Toll-like receptor 9 (TLR9) agonists suppressed the severity of experimental colitis in RAG1-/- but not in SCID mice. This differential responsiveness between phenotypically similar but genetically distinct animals was related to a partial blockade in TLR9 signaling and defective production of type I IFN (i.e., IFN… CONTINUE READING
Highly Influential
This paper has highly influenced 13 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
137 Citations
42 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 137 extracted citations


Publications referenced by this paper.
Showing 1-10 of 42 references

Toll-like receptor 9 signaling activates NF-kappaB through IFN regulatory factor-8/IFN consensus sequence binding protein in dendritic cells

  • H Tsujimura
  • J. Immunol
  • 2004
Highly Influential
9 Excerpts

Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis

  • D Rachmilewitz
  • Gas - troenterology .
  • 2004
Highly Influential
9 Excerpts

Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

  • T Kawai
  • Nat. Immunol
  • 2004
2 Excerpts

Similar Papers

Loading similar papers…