Toll-like receptor 9-dependent immune activation by unmethylated CpG motifs in Aspergillus fumigatus DNA.

@article{RamirezOrtiz2008TolllikeR9,
  title={Toll-like receptor 9-dependent immune activation by unmethylated CpG motifs in Aspergillus fumigatus DNA.},
  author={Zaida G. Ramirez-Ortiz and Charles A. Specht and Jennifer P. Wang and Chrono K. Lee and Daniella Castanheira Bartholomeu and Ricardo Tostes Gazzinelli and Stuart M Levitz},
  journal={Infection and immunity},
  year={2008},
  volume={76 5},
  pages={2123-9}
}
Phagocytic defenses are critical for effective host defenses against the opportunistic fungal pathogen Aspergillus fumigatus. Previous studies found that following challenge with A. fumigatus, Toll-like receptor 9 (TLR9) knockout mice survived longer than wild-type mice. However, the mechanism responsible was not defined. Here we demonstrate that A… CONTINUE READING