Toll-like receptor 9 agonists promote IL-8 and TGF-beta1 production via activation of nuclear factor kappaB in PC-3 cells.

@article{Di2009TolllikeR9,
  title={Toll-like receptor 9 agonists promote IL-8 and TGF-beta1 production via activation of nuclear factor kappaB in PC-3 cells.},
  author={Jin-Ming Di and Jun Pang and Xiao-yong Pu and Yan Zhang and Xiao-peng Liu and You-qiang Fang and Xing-xing Ruan and Xin Gao},
  journal={Cancer genetics and cytogenetics},
  year={2009},
  volume={192 2},
  pages={60-7}
}
Chronic infection and resulting inflammation promote tumor development and progression, and Toll-like receptors (TLRs) may play an important role in this process. The aim of this study was to determine whether CpG oligonucleotides (CpG-ODN), which are Toll-like receptor 9 (TLR9) agonists, can promote inflammatory cytokines release from the prostate cancer PC-3 cells through activation of nuclear factor-kappaB (NF-kappaB). Flow cytometry, semiquantitative real-time reverse transcriptase… CONTINUE READING

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