Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection.

@article{Albiger2007TolllikeR9,
  title={Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection.},
  author={Barbara Albiger and Sofia Dahlberg and Andreas Sandgren and Florian Wartha and Katharina Beiter and Hiroaki Katsuragi and Shizuo Akira and Staffan J. Normark and Birgitta Henriques-Normark},
  journal={Cellular microbiology},
  year={2007},
  volume={9 3},
  pages={633-44}
}
Toll-like receptor 9 (TLR9) induces an inflammatory response by recognition of unmethylated CpG dinucleotides, mainly present in prokaryotic DNA. So far, TLR9-deficient mice have been shown to be more sensitive than wild-type mice to viral, but not to bacterial infections. Here, we show that mice deficient in TLR9 but not in TLR1, TLR2, TLR4 and TLR6 or IL-1R/IL-18R are more susceptible to a respiratory tract bacterial infection caused by Streptococcus pneumoniae. Intranasal challenge studies… CONTINUE READING
71 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 71 extracted citations

Similar Papers

Loading similar papers…