Toll-like receptor 9 (TLR9) is present in murine liver sinusoidal endothelial cells (LSECs) and mediates the effect of CpG-oligonucleotides.

@article{MartinArmas2006TolllikeR9,
  title={Toll-like receptor 9 (TLR9) is present in murine liver sinusoidal endothelial cells (LSECs) and mediates the effect of CpG-oligonucleotides.},
  author={Montserrat Martin-Armas and Jaione Sim{\'o}n-Santamar{\'i}a and Ingvild Pettersen and Ugo Moens and B{\aa}rd H Smedsr\od and Baldur Sveinbj\ornsson},
  journal={Journal of hepatology},
  year={2006},
  volume={44 5},
  pages={939-46}
}
BACKGROUND/AIMS Bacterial DNA and synthetic oligonucleotides containing unmethylated motifs have become the focus of many studies due to their ability to activate cells of the innate immune system through interaction with Toll-like receptor 9 (TLR9). This study was undertaken to investigate if and how CpG-oligonucleotides (CpGs) activate liver sinusoidal endothelial cells (LSECs), known to be the main site of clearance of DNA-oligonucleotides from the circulation. METHODS Expression of TLR9… CONTINUE READING

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