Toll-like receptor-7 modulates immune complex glomerulonephritis.

  title={Toll-like receptor-7 modulates immune complex glomerulonephritis.},
  author={Rahul D Pawar and Prashant S Patole and Daniel Zecher and Stephan Segerer and Matthias Kretzler and Detlef Schloendorff and H -J Anders},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={17 1},
Viral infections may trigger immune complex glomerulonephritis via Toll-like receptors (TLR), as certain TLR trigger immunity upon recognition of viral nucleic acids. On the basis of previous findings regarding viral double-stranded RNA and TLR3 in experimental lupus erythematosus, a similar role for TLR7 that recognizes viral single-stranded RNA was hypothesized. Immunostaining of kidney sections of nephritic MRLlpr/lpr mice revealed TLR7 expression in infiltrating ER-HR3-positive macrophages… CONTINUE READING
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A Toll for

  • HJ Anders
  • 2005

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