Toll-like receptor 5 stimulation protects mice from acute Clostridium difficile colitis.

@article{Jarchum2011TolllikeR5,
  title={Toll-like receptor 5 stimulation protects mice from acute Clostridium difficile colitis.},
  author={Irene Jarchum and MingYu Liu and Lauren B Lipuma and Eric G. Pamer},
  journal={Infection and immunity},
  year={2011},
  volume={79 4},
  pages={1498-503}
}
Clostridium difficile is a spore-forming bacterium that infects the lower intestinal tract of humans and is the most common known cause of diarrhea among hospitalized patients. Clostridium difficile colitis is mediated by toxins and develops during or following antibiotic administration. We have used a murine model of C. difficile infection, which reproduces the major features of the human disease, to study the effect of innate immune activation on resistance to C. difficile infection. We found… CONTINUE READING

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