Toll-like receptor 5 agonism protects mice from radiation pneumonitis and pulmonary fibrosis.

@article{Wang2012TolllikeR5,
  title={Toll-like receptor 5 agonism protects mice from radiation pneumonitis and pulmonary fibrosis.},
  author={Zhi-dong Wang and Yu-Lei Qiao and Xi-feng Tian and Xue-qing Zhang and Shi-Xiang Zhou and Hai-Xiang Liu and Yin Chen},
  journal={Asian Pacific journal of cancer prevention : APJCP},
  year={2012},
  volume={13 9},
  pages={4763-7}
}
Radiation pneumonitis and pulmonary fibrosis are the main complications with radiotherapy for thoracic neoplasms, directly limiting the efficient dose in clinical application and currently there are few medicines that effectively function as radioprotectants. However, a TLR5 agonist, CBLB502, was confirmed to have protective efficacy against hematopoietic and gastrointestinal radiation syndromes in mice and primates. This study points to a new direction for protection against thoracic radiation… CONTINUE READING

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Identification of G-CSF and IL-6 as Candidate Biomarkers of CBLB502 Efficacy as a Medical Radiation Countermeasure

  • V Krivokrysenko, A Shakhov, V Singh
  • J Pharmacol Exp Ther,
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