Toll-like receptor 4 variants reduce airway response in human subjects at high endotoxin levels in a swine facility.

@article{Senthilselvan2009TolllikeR4,
  title={Toll-like receptor 4 variants reduce airway response in human subjects at high endotoxin levels in a swine facility.},
  author={Ambikaipakan Senthilselvan and James Arnold Dosman and Liliane Ch{\'e}nard and Lauranell H. Burch and Bernardo Z. Predicala and Randine Sorowski and David Schneberger and Tom P. Hurst and Shelley Kirychuk and Volker Gerdts and Yvon Cormier and Donna C. Rennie and David A Schwartz},
  journal={The Journal of allergy and clinical immunology},
  year={2009},
  volume={123 5},
  pages={1034-40, 1040.e1-2}
}
BACKGROUND Toll-like receptor 4 (TLR4) variants have been shown to reduce the respiratory responses to inhaled LPS in controlled experiments among healthy volunteers. OBJECTIVE We sought to investigate whether naive subjects with TLR4 variants showed reduced respiratory response to a complex aerosol including endotoxin as a major constituent. METHODS Twenty-nine nonsmoking, nonatopic healthy subjects with TLR4 299/399 polymorphisms and 29 age- and sex-matched, wild-type TLR4 control… CONTINUE READING

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