Toll-like receptor 4 stimulation initiates an inflammatory response that decreases cardiomyocyte contractility.

@article{Avlas2011TolllikeR4,
  title={Toll-like receptor 4 stimulation initiates an inflammatory response that decreases cardiomyocyte contractility.},
  author={Orna Avlas and Reut Fallach and Asher Shainberg and E. Porat and Edith Hochhauser},
  journal={Antioxidants & redox signaling},
  year={2011},
  volume={15 7},
  pages={1895-909}
}
Toll-like receptors (TLRs) have been identified as primary innate immune receptors for the recognition of pathogen-associated molecular patterns by immune cells, initiating a primary response toward invading pathogens and recruitment of the adaptive immune response. TLRs, especially Toll-like receptor 4 (TLR4), can also be stimulated by host-derived molecules and are expressed in the cardiovascular system, thus acting as a possible key link between cardiovascular diseases and the immune system… CONTINUE READING

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Mechanisms of Disease: Toll-like receptors in cardiovascular disease

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