Toll-like receptor 4 signaling by follicular dendritic cells is pivotal for germinal center onset and affinity maturation.

@article{Garin2010TolllikeR4,
  title={Toll-like receptor 4 signaling by follicular dendritic cells is pivotal for germinal center onset and affinity maturation.},
  author={Alexandre Garin and Michael Meyer-Hermann and Mathias Contie and Marc Thilo Figge and Vanessa Buatois and Matthias Gunzer and Kai-Michael Toellner and G. N. Elson and Marie H. Kosco-Vilbois},
  journal={Immunity},
  year={2010},
  volume={33 1},
  pages={84-95}
}
Germinal centers (GCs) are specialized microenvironments where antigen-activated B cells undergo proliferation, immunoglobulin (Ig) class switch recombination, somatic hypermutation (SHM), and affinity maturation. Within GCs, follicular dendritic cells (FDCs) are key players in driving these events via direct interaction with GC B cells. Here, we provide in vivo evidence that FDCs express and upregulate Toll-like-receptor (TLR) 4 in situ during germinal center reactions, confirm that their… CONTINUE READING
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