Toll-like receptor-4 mediates obesity-induced non-alcoholic steatohepatitis through activation of X-box binding protein-1 in mice.

@article{Ye2012TolllikeRM,
  title={Toll-like receptor-4 mediates obesity-induced non-alcoholic steatohepatitis through activation of X-box binding protein-1 in mice.},
  author={Dewei Ye and François Y L Li and Karen Siu-Ling. Lam and Huating Li and Weiping Jia and Yu Wang and Kwan Man and Chung-Mau Lo and Xiaokun Li and Aimin Xu},
  journal={Gut},
  year={2012},
  volume={61 7},
  pages={1058-67}
}
BACKGROUND Non-alcoholic fatty liver disease is an obesity-related chronic liver disorder ranging from simple steatosis to non-alcoholic steatohepatitis (NASH), which may progress to liver fibrosis and cirrhosis. OBJECTIVE Tto investigate the role of Toll-like receptor (TLR) 4 in mediating the transition from steatosis to inflammation. METHODS ApoE(-/-)/TLR4(mut) mice and ApoE(-/-)/TLR4 wild-type mice (ApoE(-/-)/TLR4-WT) were generated by cross-breeding an ApoE-deficient (ApoE(-/-)) strain… CONTINUE READING

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