Toll-like receptor 4-mediated regulation of spontaneous Helicobacter-dependent colitis in IL-10-deficient mice.

@article{Matharu2009TolllikeR4,
  title={Toll-like receptor 4-mediated regulation of spontaneous Helicobacter-dependent colitis in IL-10-deficient mice.},
  author={Kabir S. Matharu and Emiko Mizoguchi and Carmen Alonso Cotoner and Deanna D. Nguyen and Bethany Mingle and Onyinye I. Iweala and Megan Earley McBee and Andrew T. Stefka and Gu{\'e}nol{\'e}e Prioult and Kevin M Haigis and Atul K. Bhan and Scott B. Snapper and Hidehiro Murakami and David B. Schauer and Hans-Christian Reinecker and Atsushi Mizoguchi and Cathryn R Nagler},
  journal={Gastroenterology},
  year={2009},
  volume={137 4},
  pages={1380-90.e1-3}
}
BACKGROUND & AIMS The commensal microbiota is believed to have an important role in regulating immune responsiveness and preventing intestinal inflammation. Intestinal microbes produce signals that regulate inflammation via Toll-like receptor (TLR) signaling, but the mechanisms of this process are poorly understood. We investigated the role of the anti-inflammatory cytokine interleukin (IL)-10 in this signaling pathway using a mouse model of colitis. METHODS Clinical, histopathologic, and… CONTINUE READING