Toll-like receptor 4-mediated myeloid differentiation factor 88-dependent signaling pathway is activated by cerebral ischemia-reperfusion in hippocampal CA1 region in mice.

@article{Gao2009TolllikeR4,
  title={Toll-like receptor 4-mediated myeloid differentiation factor 88-dependent signaling pathway is activated by cerebral ischemia-reperfusion in hippocampal CA1 region in mice.},
  author={Yin Gao and Xiubin Fang and He Sun and Yu Wang and Li Jie Yao and Jing Li and Yue Ao Tong and Baohui Zhang and Yuli Liu},
  journal={Biological & pharmaceutical bulletin},
  year={2009},
  volume={32 10},
  pages={1665-71}
}
The Toll-like receptor 4 (TLR4)-mediated myeloid differentiation factor 88 (MyD88)-dependent signaling pathway plays an essential role in inflammation resulting from invading microbes. However, whether the signaling pathway is activated in the inflammatory reaction of cerebral ischemia-reperfusion and its mechanism is still unclear. In this experiment mice were randomly divided into sham group, ischemia/reperfusion group and TLR4-blocked group with different time points of reperfusion at 12, 24… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

TAK-242, an antagonist for Toll-like receptor 4, protects against acute cerebral ischemia/reperfusion injury in mice

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism • 2015

Similar Papers

Loading similar papers…