Toll-like receptor-4 is up-regulated in hematopoietic progenitor cells and contributes to increased apoptosis in myelodysplastic syndromes.

@article{Maratheftis2007TolllikeRI,
  title={Toll-like receptor-4 is up-regulated in hematopoietic progenitor cells and contributes to increased apoptosis in myelodysplastic syndromes.},
  author={Christos I Maratheftis and Evangelos Andreakos and H M Moutsopoulos and Michalis Voulgarelis},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2007},
  volume={13 4},
  pages={1154-60}
}
PURPOSE To investigate the function and expression of Toll-like receptors (TLR) in bone marrow cells of myelodysplastic syndrome (MDS) patients and to examine their involvement in the apoptotic phenomenon characterizing MDS hematopoiesis. EXPERIMENTAL DESIGN TLR mRNA and protein expression was investigated in bone marrow cell populations of MDS patients and controls. TLR-4 ability to recognize lipopolysaccharide and up-regulate self mRNA and protein expression was examined. Tumor necrosis… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 27 references

Aberrantalterna - tive splicing of interferon regulatory factor - 1 ( IRF - 1 ) in myelodysplastic hematopoietic progenitor cells

  • BolarakiPE MaratheftisCI, GiannouliS, MoutsopoulosHM Kapsogeorgou EK, VoulgarelisM
  • Leuk Res
  • 2006

A comparative review of classification systems in myelodysplastic syndromes ( MDS )

  • JM Bennett
  • Semin Oncol
  • 2005

Overexpression ofTLR 2 and TLR 4 susceptibility to serum deprivation - induced apoptosis in CHO cells

  • HaT FanW, LiY
  • Biochem Biophys Res Commun
  • 2005

Role of the p 38 mitogen - activated proteinkinasepathwayincytokine - mediatedhematopoietic suppression inmyelodysplas - tic syndromes

  • E Katsoulidis, Y Li, P Yoon
  • CancerRes
  • 2005

Similar Papers

Loading similar papers…