Toll-like receptor 4 is involved in neuroprotection afforded by ischemic preconditioning.

@article{Pradillo2009TolllikeR4,
  title={Toll-like receptor 4 is involved in neuroprotection afforded by ischemic preconditioning.},
  author={J M Pradillo and David Fern{\'a}ndez-L{\'o}pez and Isaac Garc{\'i}a-Y{\'e}benes and M{\'o}nica Sobrado and Olivia Hurtado and Mar{\'i}a {\'A}ngeles Moro and Ignacio Lizasoain},
  journal={Journal of neurochemistry},
  year={2009},
  volume={109 1},
  pages={
          287-94
        }
}
It has been demonstrated that a short ischemic event (ischemic preconditioning, IPC) results in a subsequent resistance to severe ischemia (ischemic tolerance, IT). We have recently demonstrated the role of innate immunity and in particular of toll-like receptor (TLR) 4 in brain ischemia. Several evidences suggest that TLR4 might also be involved in IT. Therefore, we have now used an in vivo model of IPC to investigate whether TLR4 is involved in IT. A 6-min temporary bilateral common carotid… CONTINUE READING
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