Toll-like receptor 4 is a regulator of monocyte and electroencephalographic responses to sleep loss.

@article{Wisor2011TolllikeR4,
  title={Toll-like receptor 4 is a regulator of monocyte and electroencephalographic responses to sleep loss.},
  author={Jonathan P. Wisor and William C Clegern and Michelle A. Schmidt},
  journal={Sleep},
  year={2011},
  volume={34 10},
  pages={1335-45}
}
STUDY OBJECTIVES Sleep loss triggers changes in inflammatory signaling pathways in the brain and periphery. The mechanisms that underlie these changes are ill-defined. The Toll-like receptor 4 (TLR4) activates inflammatory signaling cascades in response to endogenous and pathogen-associated ligands known to be elevated in association with sleep loss. TLR4 is therefore a possible mediator of some of the inflammation-related effects of sleep loss. Here we describe the baseline… CONTINUE READING