Toll-like receptor 4 involvement in hepatic ischemia/reperfusion injury in mice.

@article{Wu2004TolllikeR4,
  title={Toll-like receptor 4 involvement in hepatic ischemia/reperfusion injury in mice.},
  author={He-shui Wu and Jin-xiang Zhang and Lin Wang and Yuan Tian and Hui Wang and Ori D. Rotstein},
  journal={Hepatobiliary & pancreatic diseases international : HBPD INT},
  year={2004},
  volume={3 2},
  pages={250-3}
}
BACKGROUND Toll-like receptor 4 (TLR4) is involved in innate immunity by recognizing endotoxin resulting in a burst of inflammatory cascade. We investigated the relation between activation of TLR4 and liver injury in partial hepatic ischemia/reperfusion (I/R) injury in mice. METHODS TLR4-deficient mice (C3H/Hej) and wild type mice (WT, C3H/Heouj) were used in the model of I/R injury. Partial hepatic ischemia was produced by occlusion of inflow to the median and left lobes for 45 minutes… CONTINUE READING
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