Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide.

@article{Lien2000TolllikeR4,
  title={Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide.},
  author={Egil Lien and Terry K. Means and Henry Heine and Akihiko Yoshimura and S Kusumoto and Koichi Fukase and Matthew J. Fenton and Masa-aki Oikawa and Nilofer Qureshi and B Monks and Robert W. Finberg and Robin R. Ingalls and Douglas T Golenbock},
  journal={The Journal of clinical investigation},
  year={2000},
  volume={105 4},
  pages={
          497-504
        }
}
Lipopolysaccharide (LPS) is the main inducer of shock and death in Gram-negative sepsis. Recent evidence suggests that LPS-induced signal transduction begins with CD14-mediated activation of 1 or more Toll-like receptors (TLRs). The lipid A analogues lipid IVa and Rhodobacter sphaeroides lipid A (RSLA) exhibit an uncommon species-specific pharmacology. Both compounds inhibit the effects of LPS in human cells but display LPS-mimetic activity in hamster cells. We transfected human TLR4 or human… CONTINUE READING

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