Toll-like receptor 4 functions intracellularly in human coronary artery endothelial cells: roles of LBP and sCD14 in mediating LPS responses.

@article{Dunzendorfer2004TolllikeR4,
  title={Toll-like receptor 4 functions intracellularly in human coronary artery endothelial cells: roles of LBP and sCD14 in mediating LPS responses.},
  author={Stefan Dunzendorfer and Hyun-ku Lee and Katrin Soldau and Peter S. Tobias},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2004},
  volume={18 10},
  pages={1117-9}
}
Endothelial cells are activated by microbial agonists through Toll-like receptors (TLRs) to express inflammatory mediators; this is of significance in acute as well as chronic inflammatory states such as septic shock and atherosclerosis, respectively. We investigated mechanisms of lipopolysaccharide (LPS)-induced cell activation in human coronary artery… CONTINUE READING