Toll-like receptor 4-deficient mice have reduced bone destruction following mixed anaerobic infection.

@article{Hou2000TolllikeR4,
  title={Toll-like receptor 4-deficient mice have reduced bone destruction following mixed anaerobic infection.},
  author={Linda Hou and Hajime Sasaki and Philip P. Stashenko},
  journal={Infection and immunity},
  year={2000},
  volume={68 8},
  pages={4681-7}
}
C3H/HeJ mice have an impaired ability to respond to lipopolysaccharide (LPS) due to a mutation in the gene that encodes Toll-like receptor 4 (TLR4). The effect of TLR4 deficiency on host responses to endodontic infections is unknown. In the present study, we compared periapical bone destruction, sepsis, and inflammatory cytokine production in LPS-hyporesponsive C3H/HeJ and wild-type control C3H/HeOuJ mice. The mandibular first molars of both strains were subjected to pulpal exposure and… CONTINUE READING

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