Toll-like receptor 4 and atherogenesis.

  title={Toll-like receptor 4 and atherogenesis.},
  author={Stefan Kiechl and Christian J Wiedermann and Johann Willeit},
  journal={Annals of medicine},
  volume={35 3},
Toll-like receptor 4 (TLR4) is a pattern recognition receptor involved in the innate immune response to various microorganisms and other exogenous and endogenous stress factors. Recently, evidence emerged that important inflammatory processes implicit in human atherogenesis are mediated in part via the TLR4/nuclear factor-kappaB pathway. Polymorphisms of TLR4, which attenuate receptor signalling, enhance the risk of acute severe infections but may have opposite effects on atherogenesis. The aim… CONTINUE READING

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