Toll-like receptor 4 agonists adsorbed to aluminium hydroxide adjuvant attenuate ovalbumin-specific allergic airway disease: role of MyD88 adaptor molecule and interleukin-12/interferon-gamma axis.

@article{Bortolatto2008TolllikeR4,
  title={Toll-like receptor 4 agonists adsorbed to aluminium hydroxide adjuvant attenuate ovalbumin-specific allergic airway disease: role of MyD88 adaptor molecule and interleukin-12/interferon-gamma axis.},
  author={Juliana Bortolatto and Erica N. Borducchi and D{\'u}nia Rodriguez and Alexandre Castro Keller and E L Faquim-Mauro and Karina Ramalho Bortoluci and Daniel Mucida and Eliane Solar Gomes and A. Ralph Christ and Silvia Schnyder-Candrian and Benno Schnyder and Bernhard Ryffel and Momtchilo Russo},
  journal={Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
  year={2008},
  volume={38 10},
  pages={1668-79}
}
BACKGROUND Epidemiological and experimental data suggest that bacterial lipopolysaccharides (LPS) can either protect from or exacerbate allergic asthma. Lipopolysaccharides trigger immune responses through toll-like receptor 4 (TLR4) that in turn activates two major signalling pathways via either MyD88 or TRIF adaptor proteins. The LPS is a pro-Type 1 T helper cells (Th1) adjuvant while aluminium hydroxide (alum) is a strong Type 2 T helper cells (Th2) adjuvant, but the effect of the mixing of… CONTINUE READING

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