Toll-like receptor 4 (TLR4)-deficient murine macrophage cell line as an in vitro assay system to show TLR4-independent signaling of Bacteroides fragilis lipopolysaccharide.

Abstract

Bacterial lipopolysaccharides (LPS) activate cells of innate immunity, such as macrophages, by stimulating signaling through toll-like receptor 4 (TLR4). We and others have hypothesized that LPS derived from different bacterial species may function through TLR4-independent mechanisms. To test this hypothesis, we have generated using a nonviral… (More)

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@article{Lorenz2002TolllikeR4, title={Toll-like receptor 4 (TLR4)-deficient murine macrophage cell line as an in vitro assay system to show TLR4-independent signaling of Bacteroides fragilis lipopolysaccharide.}, author={E. P. M. Lorenz and Dhavalkumar D. Patel and Thomas Hartung and David A. Schwartz}, journal={Infection and immunity}, year={2002}, volume={70 9}, pages={4892-6} }