Toll-like receptor-3 stimulation upregulates sFLT-1 production by trophoblast cells.

@article{Nakada2009TolllikeRS,
  title={Toll-like receptor-3 stimulation upregulates sFLT-1 production by trophoblast cells.},
  author={Emiri Nakada and Keith R. Walley and Teruhiro Nakada and Yuehua Hu and Peter von Dadelszen and John H. Boyd},
  journal={Placenta},
  year={2009},
  volume={30 9},
  pages={
          774-9
        }
}
BACKGROUND Preeclampsia is characterized by a systemic inflammatory response involving cytokines, chemokines, and anti-angiogenic factors such as sFLT-1. In many other inflammatory diseases related responses are triggered by toll-like receptor (TLR) stimulation. Therefore, we tested the hypothesis that TLR stimulation of a trophoblast cell line induces inflammatory mediator production and, in particular, production of the preeclampsia-related anti-angiogenic factor sFLT-1. METHODS We… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 15 CITATIONS

Advances in Sepsis Research.

  • Clinics in chest medicine
  • 2015
VIEW 2 EXCERPTS