Toll-like receptor 3 signaling induces chronic pancreatitis through the Fas/Fas ligand-mediated cytotoxicity.

@article{Soga2009TolllikeR3,
  title={Toll-like receptor 3 signaling induces chronic pancreatitis through the Fas/Fas ligand-mediated cytotoxicity.},
  author={Yoshiko Soga and Hiroaki Komori and Tatsuhiko Miyazaki and Norimasa Arita and Miho Terada and Kazuo Kamada and Yuki Tanaka and Takahiro Fujino and Yoichi Hiasa and Bunzo Matsuura and Morikazu Onji and Masato Nose},
  journal={The Tohoku journal of experimental medicine},
  year={2009},
  volume={217 3},
  pages={175-84}
}
Innate immunity plays important roles in host defense against pathogens, but may also contribute to the development of autoimmune diseases under certain conditions. Toll-like receptors (TLRs) recognize various pathogens and induce innate immunity. We herein present a mouse model for chronic pancreatitis, which was induced by TLR3 signaling that generated the Fas/Fas ligand (FasL)-mediated cytotoxicity. An analogue of viral double-stranded RNA, polyinosinic:polycytidylic acid (poly I:C), which… CONTINUE READING