Toll-like receptor 3 pathway restricts Marek’s disease virus infection

@inproceedings{Zou2017TolllikeR3,
  title={Toll-like receptor 3 pathway restricts Marek’s disease virus infection},
  author={Haitao Zou and Ruixue Su and Jing Jing Ruan and Hong-xia Shao and Kun Qian and Jianqiang Ye and Aijian Qin},
  booktitle={Oncotarget},
  year={2017}
}
Marek's disease virus (MDV) is an α-herpesvirus that causes immune suppression and T lymphoma in chickens. Toll-like receptor 3 (TLR3) is critical for the host immune response against MDV infection. Previously, our team demonstrated that pre-treatment of TLR3 agonist poly (I:C) inhibited Marek's disease virus infection in chicken embryo fibroblasts (CEFs). However, whether TLR3 inhibits the aggravation of MDV infection is unknown. In the current study, we found that TLR3 activation in MDV… CONTINUE READING

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