Toll-like receptor 3-mediated inflammation by p38 is enhanced by endothelial nitric oxide synthase knockdown

@inproceedings{Koch2019TolllikeR3,
  title={Toll-like receptor 3-mediated inflammation by p38 is enhanced by endothelial nitric oxide synthase knockdown},
  author={Stephen R Koch and Hyehun Choi and Eric H Mace and Ryan J Stark},
  booktitle={Cell Communication and Signaling},
  year={2019}
}
AbstractBackgroundVascular dysfunction is commonly seen during severe viral infections. Endothelial nitric oxide synthase (eNOS), has been postulated to play an important role in regulating vascular homeostasis as well as propagation of the inflammatory reaction. We hypothesized that the loss of eNOS would negatively impact toll-like receptor 3 (TLR3) signaling and worsen vascular function to viral challenge.MethodsHuman microvascular endothelial cells (HMVECs) were exposed to either control or… CONTINUE READING
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