Toll-like receptor 3 expressed by melanoma cells as a target for therapy?

  title={Toll-like receptor 3 expressed by melanoma cells as a target for therapy?},
  author={Bruno Salaun and Serge J. Lebecque and Sampsa Matikainen and Donata Rimoldi and Pedro Romero},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={13 15 Pt 1},
PURPOSE The immunomodulatory properties of Toll-like receptors (TLR) agonists have inspired their use as experimental adjuvants for vaccination of cancer patients. However, it is now well recognized that TLR expression is not restricted to immune cells but can also be found in many cell types, including those giving rise to tumors. It is therefore mandatory to explore the potential effects of TLR triggering directly on tumor cells. EXPERIMENTAL DESIGN In the present work, we have investigated… CONTINUE READING


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