Toll-like receptor 3 deficiency decreases epileptogenesis in a pilocarpine model of SE-induced epilepsy in mice.

@article{Gross2017TolllikeR3,
  title={Toll-like receptor 3 deficiency decreases epileptogenesis in a pilocarpine model of SE-induced epilepsy in mice.},
  author={Adi Gross and Felix Benninger and Ravit Madar and Tomer Illouz and Kathleen J. Griffioen and Israel Steiner and Daniel Offen and Eitan Okun},
  journal={Epilepsia},
  year={2017},
  volume={58 4},
  pages={
          586-596
        }
}
OBJECTIVE Epilepsy affects 60 million people worldwide. Despite the development of antiepileptic drugs, up to 35% of patients are drug refractory with uncontrollable seizures. Toll-like receptors (TLRs) are central components of the nonspecific innate inflammatory response. Because TLR3 was recently implicated in neuronal plasticity, we hypothesized that it may contribute to the development of epilepsy after status epilepticus (SE). METHODS To test the involvement of TLR3 in epileptogenesis… CONTINUE READING
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