Toll-like receptor 3 activation induces antiviral immune responses in mouse sertoli cells.

@article{Starace2008TolllikeR3,
  title={Toll-like receptor 3 activation induces antiviral immune responses in mouse sertoli cells.},
  author={Donatella Starace and Roberta Galli and A. Paone and Paola de Cesaris and Antonio Filippini and Elio Ziparo and Anna Riccioli},
  journal={Biology of reproduction},
  year={2008},
  volume={79 4},
  pages={766-75}
}
Toll-like receptors (TLRs) recognize pathogen-associated molecular patterns and elicit antimicrobial immune responses. In the testis, viruses can induce pathological conditions, such as orchitis, and may participate in the etiology of testicular cancer; however, the molecular mechanisms involved remain under investigation. It has been suggested that because they constitutively express interferon (IFN)-inducible antiviral proteins, Sertoli cells participate in the testicular antiviral defense… CONTINUE READING

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