Toll-like receptor 2 signaling in response to brain injury: an innate bridge to neuroinflammation.

@article{Babcock2006TolllikeR2,
  title={Toll-like receptor 2 signaling in response to brain injury: an innate bridge to neuroinflammation.},
  author={Alicia Anne Babcock and Martin Wirenfeldt and Thomas Eske Holm and Helle Hvilsted Nielsen and Lasse Dissing-Olesen and Henrik Toft-Hansen and Jason Michael Millward and R{\'e}gine Landmann and Serge Rivest and Bente Finsen and Trevor Owens},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2006},
  volume={26 49},
  pages={12826-37}
}
Reactive gliosis is a prominent feature of neurodegenerative and neuroinflammatory disease in the CNS, yet the stimuli that drive this response are not known. There is growing appreciation that signaling through Toll-like receptors (TLRs), which is key to generating innate responses to infection, may have pathogen-independent roles. We show that TLR2 was selectively upregulated by microglia in the denervated zones of the hippocampus in response to stereotactic transection of axons in the… CONTINUE READING