Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands

@inproceedings{Barbalat2009TolllikeR2,
  title={Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands},
  author={Roman Barbalat and Laura Lau and Richard M Locksley and Gregory M Barton},
  booktitle={Nature Immunology},
  year={2009}
}
Despite the paradigm that the innate immune system uses nucleic acid–specific receptors to detect viruses because of a lack of other conserved features, many viruses are recognized by Toll-like receptor 2 (TLR2) and TLR4. The relevance of this recognition for antiviral immunity remains largely unexplained. Here we report that TLR2 activation by viruses led to the production of type I interferon. TLR2-dependent induction of type I interferon occurred only in response to viral ligands, which… CONTINUE READING

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