Toll-like receptor 2 mediates alveolar macrophage response to Pneumocystis murina.

@article{Zhang2006TolllikeR2,
  title={Toll-like receptor 2 mediates alveolar macrophage response to Pneumocystis murina.},
  author={Chen Zhang and Shao-Hung Wang and Mark E. Lasbury and Dennis Tschang and C Li M Liao and Pamela J. Durant and C Ellen Lee},
  journal={Infection and immunity},
  year={2006},
  volume={74 3},
  pages={1857-64}
}
The innate immune response to Pneumocystis infection is not well understood. In this study, normal C57BL/6 mouse alveolar macrophages were found to respond to Pneumocystis murina organisms through Toll-like receptor 2 (TLR2), leading to the nuclear translocation of NF-kappaB and the production of proinflammatory cytokine tumor necrosis factor alpha (TNF-alpha) and chemokine macrophage inflammatory protein 2 (MIP-2). P. murina stimulation of normal alveolar macrophages from C57BL/6 mice resulted… CONTINUE READING
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