Toll-like receptor 2 mediates CNS injury in focal cerebral ischemia

  title={Toll-like receptor 2 mediates CNS injury in focal cerebral ischemia},
  author={Seija Lehnardt and Sabrina Lehmann and David Kaul and Katharina Tschimmel and Joerg R. Weber},
  journal={Journal of Neuroimmunology},
Toll-like receptors (TLR) recognize molecular structures associated with pathogens as well as host-derived components and initiate an inflammatory innate immune response. Microglia represent the resident immune host defense and are the major inflammatory cell type in the central nervous system (CNS). We show here that TLR2-deficient mice develop a decreased CNS injury compared to wild type mice in a model of focal cerebral ischemia. TLR2 mRNA is up-regulated in wild type mice during cerebral… CONTINUE READING
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