Toll-like receptor 2-mediated intestinal injury and enteric tumor necrosis factor receptor I contribute to liver fibrosis in mice.

@article{Hartmann2012TolllikeR2,
  title={Toll-like receptor 2-mediated intestinal injury and enteric tumor necrosis factor receptor I contribute to liver fibrosis in mice.},
  author={Phillipp Hartmann and Michael Haimerl and Magdalena Mazagova and David Brenner and Bernd E. Schnabl},
  journal={Gastroenterology},
  year={2012},
  volume={143 5},
  pages={
          1330-1340.e1
        }
}
BACKGROUND & AIMS Progression of liver fibrosis in experimental models depends on gut-derived bacterial products, but little is known about mechanisms of disruption of the mucosal barrier or translocation. We used a mouse model of cholestatic liver disease to investigate mechanisms of intestinal barrier disruption following liver injury. METHODS Liver fibrosis and bacterial translocation were assessed in Toll-like receptor 2 (TLR2)-deficient and tumor necrosis factor receptor I (TNFRI… CONTINUE READING
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