Toll-like receptor 2 ligands promote chronic atopic dermatitis through IL-4-mediated suppression of IL-10.

@article{Kaesler2014TolllikeR2,
  title={Toll-like receptor 2 ligands promote chronic atopic dermatitis through IL-4-mediated suppression of IL-10.},
  author={Susanne Kaesler and Thomas Volz and Yuliya Skabytska and Martin K{\"o}berle and Ulrike Hein and Ko-Ming Chen and Emmanuella Guenova and Florian Woelbing and Martin Roecken and Tilo Biedermann},
  journal={The Journal of allergy and clinical immunology},
  year={2014},
  volume={134 1},
  pages={92-9}
}
BACKGROUND Atopic dermatitis (AD) is a T cell-mediated inflammatory skin disease, with TH2 cells initiating acute flares. This inflamed skin is immediately colonized with Staphylococcus aureus, which provides potent Toll-like receptor (TLR) 2 ligands. However, the effect of TLR2 ligands on the development of TH2-mediated AD inflammation remains unclear. OBJECTIVE We investigated the progression of TH2 cell-mediated dermatitis after TLR2 activation. METHODS Using models for acute AD with TH2… CONTINUE READING
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