Toll-like receptor 2 ligands activate human basophils for both IgE-dependent and IgE-independent secretion.

@article{Bieneman2005TolllikeR2,
  title={Toll-like receptor 2 ligands activate human basophils for both IgE-dependent and IgE-independent secretion.},
  author={Anja P. Bieneman and Kristin L. Chichester and Yi-Hsing Chen and John T. Schroeder},
  journal={The Journal of allergy and clinical immunology},
  year={2005},
  volume={115 2},
  pages={295-301}
}
BACKGROUND Toll-like receptor (TLR) molecules play a critical role in directing the course of acquired immunity, including that associated with allergic disease, by recognizing specific microbial products that activate immune cells for effector functions. OBJECTIVE We investigated whether human basophils express 2 such molecules (TLR2 and TLR4), and assessed whether putative ligands for these receptors activate nuclear factor kappaB (NFkappaB) and modulate mediator release and cytokine… CONTINUE READING
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